Category: Health News

C.DIFF BREAKTHROUGH: Genetic Lab to Share Gut Microbiome Discovery

C.DIFF BREAKTHROUGH: Genetic Lab to Share Gut Microbiome Discovery
Progenabiome, a genetic sequencing laboratory of the gut flora. Leading the way into the FUTURE by understanding the microbiome NOW. The quest for a new healthcare revolution!
Progenabiome, a genetic sequencing laboratory of the gut flora. Leading the way into the FUTURE by understanding the microbiome NOW. The quest for a new healthcare revolution!

“This data will change healthcare and make us more aware of our gut microbiome,” said Dr. Sabine Hazan-Steinberg, CEO and Founder of Progenabiome. “2500 years later, we’re proving Hippocrates right…everything starts in the gut.”

Dr. Hazan, a Malibu-based gastroenterologist, has 20+ years experience leading clinical trials, many for C.diff. When trials failed, she used fecal microbiota transplant (FMT), following advice from friend Dr. Neil Stollman, gastroenterologist at UCSF and East Bay Center for Digestive Health. She also followed great work by Dr. Thomas Borody, FMT pioneer and Centre for Digestive Diseases founder. Success post-FMT for recurrent C.diff suggested the microbiome holds many answers.

Knowing the C.diff microbe has existed for 10 million years, she questioned why it now takes 50,000 lives annually.

Dr. Sydney Finegold, infectious disease specialist who researched Autism/microbiome for 50 years, recommended she acquire a next-generation sequencer. When he passed in 2018, his books went to Hazan, hoping she could continue his legacy.

In January, she joined pathologist Dr. Brad Barrows and scientific director Dr. Andreas Papoutsis to launch Progenabiome. Their first run found non-toxigenic C.diff in every sample, including those not diagnosed with the disease. Preliminary data shows the C.diff microbe is not transmitted hand-to-mouth as previously believed. It is already in the gut and becomes toxic when something ingested triggers it.

Progenabiome will present this groundbreaking discovery at ACG 2019 (Poster 1027 / Booth 1931) and the 7th Annual International C.diff Conference November 6-7, 2019 in St. Louis.

Progenabiome is investigating the role of the gut flora in various diseases through 11 studies overlooked by New England IRB. Progenabiome’s Mission: to better understand, prevent, and treat diseases by analyzing specific genetic codes of 40 trillion gut microbes. Dr. Hazan believes the art of Medicine lies in our ability to see outside the box and recognize that all microbes and humans are unique.

For more: progenabiome.com / Twitter / Facebook / LinkedIn

Contact: Stephanie Davis, marketing@progenabiome.com

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Dr. Sabine Hazan & ProgenaBiome

Dr. Sabine Hazan & ProgenaBiome

Dr. Sabine Hazan, Our Start!

Born in Morocco, Dr. Sabine Hazan has always been dedicated to understanding life. She sought a career in medicine and was accepted to medical school based on outstanding research on obesity conducted as an undergraduate. She completed her residency at the University of Miami during the peak of the HIV epidemic, treating extremely ill patients at Jackson Memorial Hospital and in the local jail. There, she was awarded two prizes for her research. After completing her residency, Dr. Hazan became the first woman gastroenterology fellow at the University of Florida. There, she completed a year of research and presented her findings in poster format at the American College of Gastroenterology (ACG) National Meeting. It was at that moment that she was approached by the esteemed Dr. Neil Stollman. He told her that the future of medicine lies in the microbiome. For her exceptional work with visceral hyperalgesia she was awarded the Dean’s Research Award. Dr. Stollman is now an expert and leader on fecal transplant and Clostridioidesdifficile (C.diff) and serves on the governing board of the ACG.

Following her fellowship, Dr. Hazan returned to Montreal and opened a practice in upstate New York. Her work there consisted of 10 percent research and 90 percent private gastroenterology patients and brought many patients from across the border in Canada. She was the only female gastroenterologist in an 80-mile radius, and the influx of Canadian patients brought to light for her the problems with socialized medicine in Canada. These patients faced intolerable wait times for a visit with a gastroenterologist in Canada, and so visited Dr. Hazan in New York. After meeting with the Prime Minister of Health, Dr. Hazan helped bring about a dual system in Canada, in which private practices co-exist with socialized medicine. Her years of practice as a solo woman gastroenterologist brought her under the microscope on numerous occasions, facing scrutiny not encountered by her male colleagues. 

After the birth of her two children, Dr. Hazan and her husband Dr. Alon Steinberg moved to California. There, she joined her sister, Dr. Lydie Hazan, at Axis Today Clinical Trials as a Sub-Investigator, and began doing clinical trial research in California for the company in Beverly Hills. She also joined a medical group as a private practitioner in Ventura. However, her desire for innovation led her to establish thriving private practices in Malibu, Thousand Oaks, and Ventura. Still desiring to understand life, she started her own clinical trial company 16 years ago, Ventura Clinical Trials, and has been Principal Investigator and Sub Investigator in over 150 clinical trials. Many of these trials were for Clostridioides difficile infection (CDI), enough that through her impressive recruitment she became known as the Queen of C. difficile in the clinical trial community. When her patients with C.diff did not respond to traditional or clinical trial therapies, she resorted to treatment with fecal microbiota transplant. 

During her extensive clinical trial experience, Dr. Hazan observed how dramatically the microbiome can impact human health. Over the years, she followed the wise words of Dr. Stollman and explored the path of FMT. She observed that FMT has the power to cure more than C.diff infection, as she saw patients with Crohn’s, psoriasis, Alzheimer’s, and even cancer improve following transplant. Naturally, this dedicated scientist wanted to better understand the mechanism behind what she was seeing in her patients. She conducted extensive research, which led her to Dr. Sydney Finegold, an infectious disease specialist, who was also focused on the microbiome and its relationship to disease, particularly Autism. He told her that the answer lies in the bacteria of the gut, and that sequencing the microbiome to identify those bacteria was the answer. He advised her to acquire a next-generation sequencer and conduct studies using whole-genome shotgun sequencing to examine the mysteries of the microbiome.

As her clinical trial work continued, Dr. Hazan found that Fecal Microbiota Transplantation (FMT) was increasingly juxtaposed to her studies. While being a top recruiter for studies, she also treated two Crohn’s patients who developed CDI and required FMT. As the patients experienced symptom relief post-FMT,  Dr. Hazan discovered that FMT allowed her to improve their Crohn’s and restore the balance of their microbiome. Wanting to better understand how this was possible, she reached out to Dr. Thomas Borody, a pioneer researcher and father of modern FMT in the 1980s. 1984 Borody established the Centre for Digestive Diseases (CDD) in Sydney, Australia and has overseen its growth into an active clinical research institute with 65 employees. In 1985, Borody pioneered the first effective triple antibiotic therapy for Helicobater pylori, which had a profound impact on curing  hundreds of patients of their peptic ulcers. His clinic has completed close to 30,000 FMT treatments, and he has filed over 165 patents. The meeting between Dr. Borody and Dr. Hazan proved to be the beginning of a great collaborative relationship.

While the Woolsey fire ravaged southern California, Dr. Hazan received a call from the family of Dr. Finegold, to inform her that she would receive all his papers and books in hopes to continue his work on Autism. Continuing his legacy, she established a new company, ProgenaBiome™,  in January 2019 to investigate the microbiome. ProgenaBiome™ is a state-of-the-art genetic research sequencing laboratory with next-generation whole genome shotgun sequencing capabilities on-site as per Dr. Sydney Finegold’s recommendations. To run this incredible laboratory, Dr. Hazan brought on board Dr. Andreas Papoutsis, a brilliant scientist with extensive experience in assay development and next-generation sequencing. He researched and investigated new technologies for the analysis of BRCA-1, one of the genes associated with breast cancer, CART-19, a therapy for blood cancers, and T-cell receptors. Under his directorship the lab has officially launched with efficient workflow and meticulous processing. 

Through her groundbreaking work, Dr. Hazan has earned the respect and admiration of her colleagues, many of whom have joined her in the quest for a healthcare revolution and helped her create the Malibu MIcrobiome Meeting. While she is working to bring medicine to new frontiers, she believes there will always be a place for pharmaceutical clinical trials, naturopaths, nutritionists, and additional work on the microbiome. She believes that the answers will come not through competition, but rather through collaboration by all fields. Just as the post office still exists, decades after the development of e-mail, better understanding of the microbiome does not eliminate the need for other facets of medicine. She also believes in patient choice; that patients should be able to choose quality of life over quantity if they so desire and have the right to try any treatment of their choosing.

Dr. Hazan has been invited to speak all over the world, including at the Microbiome Congress and NIST. She is working with both to ensure that data generated by ProgenaBiome™ is valid, verified, and reproducible, which she believes can only be achieved through ethical research.

Dr. Hazan is a firm believer that disease can only be understood through precision medicine by focusing on the individual and the changes within. Much like each person has unique fingerprints, no two people have the same microbiome. She also believes in the importance of assessing disease by looking at family. Her overall goal is to understand the microbes that allow us to function, from those we are born with to those that will decompose us when we die. She hopes that her quest for individual microbiome understanding leads to an awareness we are simply a diverse collection of microbes, working together to shape the world.

For more: progenabiome.com / Twitter / Facebook / LinkedIn

Contact: Stephanie Davis, marketing@progenabiome.com

This will change healthcare and make us more aware of our gut microbiome

Dr. Sabine Hazan-Steinberg and the the microbiome

This data will change healthcare and make us more aware of our gut microbiome

Progenabiome, a physician-owned genetic sequencing laboratory, found cutting-edge data on Clostridium difficile (C.diff), a disease burdening 500,000+ Americans yearly. They will present a validated, verified, and reproduced C.diff Assay at The American College of Gastroenterology (ACG) 2019 Annual Scientific Meeting on Monday, Oct. 28, 2019 in San Antonio.

Progenabiome, a genetic sequencing laboratory of the gut flora. Leading the way into the FUTURE by understanding the microbiome NOW. The quest for a new healthcare revolution!
Progenabiome, a genetic sequencing laboratory of the gut flora. Leading the way into the FUTURE by understanding the microbiome NOW. The quest for a new healthcare revolution!

“This data will change healthcare and make us more aware of our gut microbiome,” said Dr. Sabine Hazan-Steinberg, CEO and Founder of Progenabiome. “2500 years later, we’re proving Hippocrates right…everything starts in the gut.”

Dr. Hazan, a Malibu-based gastroenterologist, has 20+ years experience leading clinical trials, many for C.diff. When trials failed, she used fecal microbiota transplant (FMT), following advice from friend Dr. Neil Stollman, gastroenterologist at UCSF and East Bay Center for Digestive Health. She also followed great work by Dr. Thomas Borody, FMT pioneer and Centre for Digestive Diseases founder. Success post-FMT for recurrent C.diff suggested the microbiome holds many answers.

Knowing the C.diff microbe has existed for 10 million years, she questioned why it now takes 50,000 lives annually.

Dr. Sydney Finegold, infectious disease specialist who researched Autism/microbiome for 50 years, recommended she acquire a next-generation sequencer. When he passed in 2018, his books went to Hazan, hoping she could continue his legacy.

In January, she joined pathologist Dr. Brad Barrows and scientific director Dr. Andreas Papoutsis to launch Progenabiome. Their first run found non-toxigenic C.diff in every sample, including those not diagnosed with the disease. Preliminary data shows the C.diff microbe is not transmitted hand-to-mouth as previously believed. It is already in the gut and becomes toxic when something ingested triggers it.

Progenabiome will present this groundbreaking discovery at ACG 2019 (Poster 1027 / Booth 1931) and the 7th Annual International C.diff Conference November 6-7, 2019 in St. Louis.

Progenabiome is investigating the role of the gut flora in various diseases through 11 studies overlooked by New England IRB. Progenabiome’s Mission: to better understand, prevent, and treat diseases by analyzing specific genetic codes of 40 trillion gut microbes. Dr. Hazan believes the art of Medicine lies in our ability to see outside the box and recognize that all microbes and humans are unique.

For more: progenabiome.com / Twitter / Facebook / LinkedIn

Contact: Stephanie Davis, marketing@progenabiome.com

Dr Sabine Hazan from Progenabiome on Her Startup Company as well as clinical research

ProgenaBiome™

  • A genetic research lab whose interest is to understand the clinical implications of the microbiome. Our broad array of specialties allows us to look beyond fecal transplant to examine other fields of medicine in which dysbiosis could be the culprit of disease.
  • In collaboration with leading physicians in multiple specialties, spearheads the movement of validating, verifying, and clinically applying its sequencing data, to better understand the microbiome.

We are taking the microbiome to the clinical level to better understand disease, so that it may be better treated and prevented. 

Understands

ProgenaBiome™ understands that everyone is different and each person has their own unique microbiome.

Provides

ProgenaBiome™ provides DNA testing and microbiome testing to empower you to seek better health

Believes

ProgenaBiome™ believes that in order to find the best donor for fecal transplant, you must understand the microbiome of the donor.

Disclaimer – Protecting Your Privacy microbiome

ProgenaBiome™ does NOT sell your patients identifying data to pharmaceutical companies or anyone else. We are HIPAA Compliant. We are a physician-owned genetic research sequencing laboratory who work with regulatory bodies, FDA and Department of Health in hopes to understand the microbiome.

 

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